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Colorimetric Detection of Mercuric Ion (Hg 2+ ) in Aqueous Media using DNA‐Functionalized Gold Nanoparticles
Author(s) -
Lee JaeSeung,
Han Min Su,
Mirkin Chad A.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200700269
Subject(s) - colloidal gold , aqueous solution , ion , aqueous medium , nanoparticle , chemistry , mercury (programming language) , nuclear chemistry , radiochemistry , inorganic chemistry , dna , nanotechnology , materials science , organic chemistry , computer science , biochemistry , programming language
Color is everything : Hg 2+ in aqueous media is detected by the formation of thymidine–Hg 2+ –thymidine coordination complexes, which raises the melting temperature of the DNA‐hybridized gold nanoparticle probes and thus the temperature at which the probes disperse and effect a purple‐to‐red color change. The method has very high sensitivity and selectivity, and it provides a simple and fast colorimetric readout (see picture).