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A Small Molecule Targeting the Multifactorial Nature of Alzheimer's Disease
Author(s) -
Cavalli Andrea,
Bolognesi Maria Laura,
Capsoni Simona,
Andrisano Vincenza,
Bartolini Manuela,
Margotti Elisa,
Cattaneo Antonino,
Recanatini Maurizio,
Melchiorre Carlo
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200700256
Subject(s) - acetylcholinesterase , neuroscience , disease , sight , alzheimer's disease , amyloid β , small molecule , enzyme , psychology , medicine , chemistry , biochemistry , physics , astronomy
Sights set on a cure : Memoquin ( 1 ) affects several mechanisms relevant to Alzheimer's disease (AD): the formation of reactive oxygen species, the processing and aggregation of amyloid β (Aβ) peptides, and acetylcholinesterase activity. In animal models, 1 causes a remarkable decrease in the formation of AD neurodegenerative hallmarks and a significant reversal of behavioral deficits. hAChE, BACE‐1, and NQO1 are enzymes targeted by 1 .