A Small Molecule Targeting the Multifactorial Nature of Alzheimer's Disease | Zendy

Cavalli Andrea | Zendy; Bolognesi Maria Laura | Zendy; Capsoni Simona | Zendy; Andrisano Vincenza | Zendy; Bartolini Manuela | Zendy; Margotti Elisa | Zendy; Cattaneo Antonino | Zendy; Recanatini Maurizio | Zendy; Melchiorre Carlo | Zendy

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A Small Molecule Targeting the Multifactorial Nature of Alzheimer's Disease

Author(s) -

Cavalli Andrea,

Bolognesi Maria Laura,

Capsoni Simona,

Andrisano Vincenza,

Bartolini Manuela,

Margotti Elisa,

Cattaneo Antonino,

Recanatini Maurizio,

Melchiorre Carlo

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200700256

Subject(s) - acetylcholinesterase , neuroscience , disease , sight , alzheimer's disease , amyloid β , small molecule , enzyme , psychology , medicine , chemistry , biochemistry , physics , astronomy

Sights set on a cure : Memoquin ( 1 ) affects several mechanisms relevant to Alzheimer's disease (AD): the formation of reactive oxygen species, the processing and aggregation of amyloid β (Aβ) peptides, and acetylcholinesterase activity. In animal models, 1 causes a remarkable decrease in the formation of AD neurodegenerative hallmarks and a significant reversal of behavioral deficits. hAChE, BACE‐1, and NQO1 are enzymes targeted by 1 .

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