Premium
A Highly Selective, High‐Speed, and Hydrolysis‐Free O‐Acylation in Subcritical Water in the Absence of a Catalyst
Author(s) -
Sato Masahiro,
Matsushima Keiichiro,
Kawanami Hajime,
Ikuhsima Yutaka
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200700180
Subject(s) - acylation , acetic anhydride , regioselectivity , hydrolysis , catalysis , chemistry , organic chemistry
Fast and furious : A wide range of alcohols are acylated by acetic anhydride, in the absence of catalyst, in subcritical water in a flow‐type microreaction system. The esters are selectively produced in high yields at temperatures of 200 to 250 °C. Varying the amount of acetic anhydride added with respect to the alcohols allows the regioselective acylation of one or both hydroxy groups of various dihydroxy compounds (see picture).