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Synthesis of 1,2‐Disubstituted Benzimidazoles by a Cu‐Catalyzed Cascade Aryl Amination/Condensation Process
Author(s) -
Zou Benli,
Yuan Qiliang,
Ma Dawei
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200700071
Subject(s) - benzimidazole , amination , substituent , chemistry , aryl , dimethyl sulfoxide , condensation , catalysis , ring (chemistry) , combinatorial chemistry , sulfoxide , copper , medicinal chemistry , organic chemistry , alkyl , physics , thermodynamics
Helpful neighbors : A wide range of 1,2‐disubstituted benzimidazoles can be assembled from 2‐haloanilides and primary amines by using a copper‐catalyzed amination reaction promoted by an ortho ‐substituent effect of an NHCOR group (see scheme, DMSO=dimethyl sulfoxide). The strategy also permits a broad array of substituents X at different positions of the benzimidazole phenyl ring.