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The Renaissance of H/D Exchange
Author(s) -
Atzrodt Jens,
Derdau Volker,
Fey Thorsten,
Zimmermann Jochen
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200700039
Subject(s) - deuterium , hydrogen–deuterium exchange , the renaissance , chemistry , mass spectrometry , molecule , hydrogen , combinatorial chemistry , radiochemistry , organic chemistry , chromatography , nuclear physics , physics , art , art history
The increasing demand for stable isotopically labeled compounds has led to an increased interest in H/D‐exchange reactions at carbon centers. Today deuterium‐labeled compounds are used as internal standards in mass spectrometry or to help elucidate mechanistic theories. Access to these deuterated compounds takes place significantly more efficiently and more cost effectively by exchange of hydrogen by deuterium in the target molecule than by classical synthesis. This Review will concentrate on the preparative application of the H/D‐exchange reaction in the preparation of deuterium‐labeled compounds. Advances over the last ten years are brought together and critically evaluated.