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Cover Picture: Toward the Total Synthesis of Spirastrellolide A. Part 1: Strategic Considerations and Preparation of the Southern Domain / Toward the Total Synthesis of Spirastrellolide A. Part 2: Conquest of the Northern Hemisphere (Angew. Chem. Int. Ed. 33/2006)
Author(s) -
Fürstner Alois,
Fenster Michaël D. B.,
Fasching Bernhard,
Godbout Cédrickx,
Radkowski Karin
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200690112
Subject(s) - conquest , cover (algebra) , total synthesis , product (mathematics) , domain (mathematical analysis) , computer science , mathematics , history , engineering , chemistry , stereochemistry , geometry , ancient history , mechanical engineering , mathematical analysis
The antimitotic natural product spirastrellolide A is a complicated structure that shows impressive biological effects. Many key issues remain unresolved for this compound, for example its relative and absolute configurations and its biological mode of action. In two Communications on pages 5506 and 5510 ff., Fürstner and co‐workers describe the synthesis of all four fragments of spirastrellolide A—initial strides in answering these questions. (Image of cell undergoing mitosis: Conley Rieder.)