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Cover Picture: Kinetically Controlled Ligation for the Convergent Chemical Synthesis of Proteins (Angew. Chem. Int. Ed. 24/2006)
Author(s) -
Bang Duhee,
Pentelute Brad L.,
Kent Stephen B. H.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200690082
Subject(s) - native chemical ligation , ligation , chemical ligation , peptide , molecule , chemistry , cover (algebra) , chemical synthesis , combinatorial chemistry , stereochemistry , biochemistry , organic chemistry , biology , microbiology and biotechnology , engineering , mechanical engineering , in vitro
Convergent chemical ligation enables the more efficient total synthesis of protein molecules. S. B. H. Kent and co‐workers describe in their Communication on page 3985 ff. how the two halves of the target peptide chain can be synthesized by kinetically controlled chemical ligation of unprotected peptide segments. A final native chemical ligation step then gives the full‐length polypeptide chain, which folds with high efficiency to give the synthetic protein molecule. (The artwork for the coverpicture was prepared by David Boerema.)