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Cover Picture: Identification of Pyridinylpyrimidines as Inhibitors of Human Methionine Aminopeptidases (Angew. Chem. Int. Ed. 23/2006)
Author(s) -
Hu Xiaoyi,
Addlagatta Anthony,
Matthews Brian W.,
Liu Jun O.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200690079
Subject(s) - methionine , int , enzyme , biochemistry , chemistry , protein function , structural similarity , computational biology , biology , amino acid , computer science , gene , operating system
The evolutionarily conserved enzymes , the methionine aminopeptidases (MetAPs), remove N‐terminal methionine during protein synthesis. J. O. Liu et al. describe in their Communication on page 3772 ff. a new class of inhibitors for MetAPs and the crystal structure of the inhibitor complexed with MetAP1. These findings should facilitate the development of MetAP1‐specific inhibitors that can serve as molecular probes for the function of MetAP1 and as potential leads for inhibitors of cancer cell growth.