Premium
Cover Picture: Proteolytic Actuation of Nanoparticle Self‐Assembly (Angew. Chem. Int. Ed. 19/2006)
Author(s) -
Harris Todd J.,
von Maltzahn Geoffrey,
Derfus Austin M.,
Ruoslahti Erkki,
Bhatia Sangeeta N.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200690067
Subject(s) - proteases , nanoparticle , cleavage (geology) , protease , steric effects , polymer , biophysics , chemistry , nanotechnology , materials science , stereochemistry , biochemistry , enzyme , biology , organic chemistry , fracture (geology) , composite material
Sterically shielded … … nanoparticles diffuse freely in solution and biological fluids until proteases expressed by cancer cells trigger them to self‐assemble. In their Communication on page 3161ff., S. N. Bhatia and co‐workers show that complimentary Fe 3 O 4 nanoparticle binding is inhibited by the attachment of protease‐cleavable polymers. Cleavage of these polymers triggers “latent” nanoparticles to form multimeric assemblies with emergent properties.