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Cover Picture: Flattened Cone 2,8,14,20‐Tetrakis( L ‐valinamido)[4]resorcinarene: An Enantioselective Allosteric Receptor in the Gas Phase (Angew. Chem. Int. Ed. 17/2006)
Author(s) -
Botta Bruno,
Caporuscio Fabiana,
Subissati Deborah,
Tafi Andrea,
Botta Maurizio,
Filippi Antonello,
Speranza Maurizio
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200690060
Subject(s) - enantioselective synthesis , chemistry , int , allosteric regulation , resorcinarene , stereochemistry , calixarene , gas phase , receptor , organic chemistry , biochemistry , catalysis , molecule , computer science , operating system
Protein allosterism is the basis for the molecular control of fundamental processes in living systems, but despite its importance, basic questions on the mechanisms involved remain unanswered. A gas‐phase approach to the problem is described by M. Speranza et al. in their Communication on page 2717 ff., in which they report the highly enantioselective, 2‐aminobutane‐induced loss of D ‐ and L ‐tryptophan from the achiral hydrophobic rim of a chiral resorcin[4]arene.
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