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Cover Picture: Enantioselective Catalysis and Analysis on a Chip (Angew. Chem. Int. Ed. 15/2006)
Author(s) -
Belder Detlev,
Ludwig Martin,
Wang LiWen,
Reetz Manfred T.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200690053
Subject(s) - enantioselective synthesis , kinetic resolution , int , cover (algebra) , chemistry , chip , microfluidic chip , combinatorial chemistry , catalysis , stereochemistry , microfluidics , nanotechnology , materials science , organic chemistry , computer science , engineering , telecommunications , operating system , mechanical engineering
Synthesis and analysis on a chip are possible with the microfluidic system shown (a two‐Euro coin is shown for scale). D. Belder, M. T. Reetz et al. show in their Communication on page 2463 ff. how this chip is used to test enantioselective biocatalysts created by directed evolution. The model system used is the hydrolitic kinetic resolution of chiral glycidyl phenyl ether with different epoxide hydrolase mutants. Aided by integrated electrophoreses, chiral separation of the products is possible within 80 s.