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Cover Picture: Autonomous Fueled Mechanical Replication of Nucleic Acid Templates for the Amplified Optical Detection of DNA (Angew. Chem. Int. Ed. 14/2006)
Author(s) -
Weizmann Yossi,
Cheglakov Zoya,
Pavlov Valeri,
Willner Itamar
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200690048
Subject(s) - dna , replication (statistics) , nucleic acid , template , substrate (aquarium) , chemistry , nanotechnology , biophysics , materials science , biology , biochemistry , virology , ecology
A catalytic cutter for the sensitive detection of a target DNA, a Tay–Sachs disorder mutant, is described by I. Willner and co‐workers in their Communication on page 2238 ff. As the cover picture shows, a tailored nucleic acid hairpin probe (top) is opened upon hybridization with the analyte DNA, activating the formation of the DNA cutter (central structure), which initiates the autonomous scission of a fuel substrate that leads to the replication of the catalytic cutter and to the formation of a fluorescent product as an optical readout signal.