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Cover Picture: Asymmetric Intramolecular Crossed‐Benzoin Reactions by N‐Heterocyclic Carbene Catalysis (Angew. Chem. Int. Ed. 9/2006)
Author(s) -
Enders Dieter,
Niemeier Oliver,
Balensiefer Tim
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200690029
Subject(s) - carbene , stereocenter , enantioselective synthesis , benzoin , intramolecular force , chemistry , catalysis , organocatalysis , umpolung , enantiomer , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , nucleophile
Enantioselective intramolecular crossed‐benzoin reactions can be effected by using chiral N‐heterocyclic carbene catalysts. The tetracyclic chiral carbene catalyst shown in the cover picture enables the reaction to proceed with formation of only one enantiomer of the α‐hydroxy‐substituted tetralones. D. Enders and co‐workers disclose the development of the quaternary stereocenters in the organocatalytic reaction in their Communication on page 1463 ff.