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Phloroglucinol Derivatives Guttiferone G, Aristoforin, and Hyperforin: Inhibitors of Human Sirtuins SIRT1 and SIRT2
Author(s) -
Gey Claudia,
Kyrylenko Sergiy,
Hennig Lothar,
Nguyen LienHoa D.,
Büttner Anita,
Pham Hung D.,
Giannis Athanassios
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200605207
Subject(s) - hyperforin , phloroglucinol , sirtuin , sirt2 , epigenetics , chemistry , computational biology , cancer , acetylation , biochemistry , pharmacology , biology , hypericum perforatum , gene , genetics , organic chemistry
Preventative medicine : The natural products guttiferone G and hyperforin ( 1 ) as well as the synthetic aristoforin ( 2 ) are inhibitors of human SIRT1 and SIRT2. Guttiferone G and 2 are less toxic but stronger inhibitors of cell proliferation than 1 . These compounds may be valuable tools for epigenetics and for the elucidation of the biological role of sirtuins in processes such as cancer, ageing, neurodegenerative diseases, adipositas, and diabetes.