NMR‐Guided Fragment‐Based Approach for the Design of tRNA Lys3  Ligands | Zendy

Chung Florence | Zendy; Tisné Carine | Zendy; Lecourt Thomas | Zendy; Dardel Frédéric | Zendy; Micouin Laurent | Zendy

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NMR‐Guided Fragment‐Based Approach for the Design of tRNA Lys3 Ligands

Author(s) -

Chung Florence,

Tisné Carine,

Lecourt Thomas,

Dardel Frédéric,

Micouin Laurent

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200605201

Subject(s) - chemistry , dissociation constant , ligand (biochemistry) , dissociation (chemistry) , fragment (logic) , stereochemistry , transfer rna , crystallography , organic chemistry , mathematics , biochemistry , rna , receptor , algorithm , gene

Two in one : Two ligands for tRNA Lys3 that were identified from a compound library by flow‐injection NMR spectroscopic screening and found to have millimolar dissociation constants (on the left in the picture) inspired the fragment‐based synthesis of a new family of ligands with the general structural features of both initial compounds. Ligand 1 of this family is a selective D‐stem binder of tRNA Lys3 with a micromolar K d value.

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