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Stereospecific Alkyne Reduction: Novel Activity of Old Yellow Enzymes
Author(s) -
Müller André,
Stürmer Rainer,
Hauer Bernhard,
Rosche Bettina
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200605179
Subject(s) - alkyne , stereospecificity , stereoselectivity , double bond , enzyme , triple bond , chemistry , biotransformation , reduction (mathematics) , stereochemistry , organic chemistry , catalysis , geometry , mathematics
Old enzyme, new trick : An environmentally sustainable alternative for the regio‐ and stereoselective reduction of the alkyne bond is the biotransformation by “Old Yellow Enzyme” (OYE). This “old” enzyme, first isolated in 1932, catalyzes the trans ‐selective hydrogenation of the carbon–carbon triple bond under mild conditions.