Synthesis of Cyclohexanol Derivatives by Zirconocene‐Mediated Ring‐Contraction Reactions of Seven‐Membered Cyclic Enol Ethers | Zendy

Barluenga José | Zendy; ÁlvarezRodrigo Lucía | Zendy; Rodríguez Félix | Zendy; Fañanás Francisco J. | Zendy; Sordo Tomás L. | Zendy; Campomanes Pablo | Zendy

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Synthesis of Cyclohexanol Derivatives by Zirconocene‐Mediated Ring‐Contraction Reactions of Seven‐Membered Cyclic Enol Ethers

Author(s) -

Barluenga José,

ÁlvarezRodrigo Lucía,

Rodríguez Félix,

Fañanás Francisco J.,

Sordo Tomás L.,

Campomanes Pablo

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200605172

Subject(s) - stereocenter , cyclohexanol , chemistry , electrophile , enol , reagent , cyclohexanone , ring (chemistry) , ether , medicinal chemistry , organic chemistry , enantioselective synthesis , catalysis

Shrinking the circle : Complex cyclohexanol derivatives with up to four new stereogenic centers are easily obtained by simple one‐pot, three‐component, zirconium‐mediated coupling of an alkyllithium or Grignard reagent, a seven‐membered cyclic enol ether, and an electrophile (E, see scheme).

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