Auxiliary‐Mediated Site‐Specific Peptide Ubiquitylation | Zendy

Chatterjee Champak | Zendy; McGinty Robert K. | Zendy; Pellois JeanPhilippe | Zendy; Muir Tom W. | Zendy

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Auxiliary‐Mediated Site‐Specific Peptide Ubiquitylation

Author(s) -

Chatterjee Champak,

McGinty Robert K.,

Pellois JeanPhilippe,

Muir Tom W.

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200605155

Subject(s) - ubiquitin , peptide , lysine , substrate (aquarium) , ligation , chemistry , terminal (telecommunication) , histone , photodissociation , product (mathematics) , deubiquitinating enzyme , biochemistry , computational biology , computer science , biology , microbiology and biotechnology , amino acid , mathematics , organic chemistry , telecommunications , ecology , gene , geometry

Lighting up ubiquitylation : A photolytically removable ligation auxiliary (Aux) was employed for the site‐specific attachment of ubiquitin (Ub) to one of three lysine residues in a C‐terminal peptide fragment of histone H2B (cH2B). Following photolysis, the ligation product was a viable substrate for the ubiquitin C‐terminal hydrolase UCH‐L3.

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