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Exploiting the Directionality of DNA: Controlled Shrinkage of Engineered Oligonucleotide Capsules
Author(s) -
Johnston Angus P. R.,
Caruso Frank
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200605135
Subject(s) - shrinkage , oligonucleotide , directionality , dna , drug delivery , computer science , nanotechnology , materials science , biology , microbiology and biotechnology , genetics , machine learning
Shrinking capsules : Using the directionality of DNA hybridization, DNA capsules with controllable shrinkage properties are formed (see picture). The degree of shrinkage ranges from 35–90 % of the original particle volume, depending on the oligonucleotide sequences used to assemble the capsules. These capsules could find use in drug delivery and diagnostic applications.