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C 2 ‐Symmetric Metacyclophanes: A Possible Alternative to o , o ′‐Bridged Binaphthyls
Author(s) -
Haberhauer Gebhard
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200605098
Subject(s) - stereochemistry , chemistry , crystallography
The trick with the chiral clamp: In metacyclophanes such as ( P )‐ 2 it is possible to stabilize one chiral conformation by means of a chiral clamp so effectively that at room temperature only this conformation is present. This conformation resembles that of o , o ′‐bridged binaphthyls (for example ( P )‐ 1 ). New binaphthyl alternatives are thus made accessible.