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Double Insertion of Isocyanides into Dihydropyridines: Direct Access to Substituted Benzimidazolium Salts
Author(s) -
Masdeu Carme,
Gómez Elena,
Williams Nana Aba O.,
Lavilla Rodolfo
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200605070
Subject(s) - isocyanide , benzimidazole , chemistry , combinatorial chemistry , dihydropyridine , ring (chemistry) , molecule , cascade , stereochemistry , organic chemistry , calcium , chromatography
Double agent : The insertion of two isocyanide molecules into the dihydropyridine ring in the presence of iodine results in the formation of a benzimidazole core (see scheme). Four bonds are generated (bold lines) in a highly efficient and atom‐economical manner. Access to a range of benzimidazolium derivatives is possible through a cascade reaction.