Modulating the Reactivity of α‐Isocyanoacetates: Multicomponent Synthesis of 5‐Methoxyoxazoles and Furopyrrolones | Zendy

Bonne Damien | Zendy; Dekhane Mouloud | Zendy; Zhu Jieping | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Modulating the Reactivity of α‐Isocyanoacetates: Multicomponent Synthesis of 5‐Methoxyoxazoles and Furopyrrolones

Author(s) -

Bonne Damien,

Dekhane Mouloud,

Zhu Jieping

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200605005

Subject(s) - reactivity (psychology) , nucleophile , aryl , conjugate , component (thermodynamics) , alkyl , chemistry , base (topology) , combinatorial chemistry , organic chemistry , catalysis , mathematics , physics , medicine , mathematical analysis , alternative medicine , pathology , thermodynamics

A simple approach to complexity : The reactivity pattern of α‐isocyanoacetates can be tuned by modulating the acidity of the α CH bond(s) against the nucleophilicity of the conjugate base. The unique reactivity of the α‐( p ‐nitrophenyl)‐α‐isocyanoacetate 1 was exploited in a three‐component synthesis of 5‐methoxyoxazoles 2 and four‐component synthesis of furopyrrolones 3 . R 1 ,R 2 ,R 3 =alkyl, aryl, benzyl; R 4 =aryl.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research