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Prediction of Perception: Probing the hOR17‐4 Olfactory Receptor Model with Silicon Analogues of Bourgeonal and Lilial
Author(s) -
Doszczak Leszek,
Kraft Philip,
Weber HansPeter,
Bertermann Rüdiger,
Triller Annika,
Hatt Hanns,
Tacke Reinhold
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200605002
Subject(s) - in silico , odor , olfactory receptor , olfaction , sensibility , receptor , in vitro , in vivo , chemistry , biology , neuroscience , biochemistry , gene , genetics , art , literature
Sense and sensibility : Silicon analogues of the lily‐of‐the‐valley odorants lilial and bourgeonal demonstrate that the electronic surface structure determines the interaction of an odorant with its olfactory receptor. The subtle changes in the stereoelectronic properties enable a comparison of in vivo, in vitro, and in silico data. Odor thresholds, as well as the swimming behavior of sperm cells, correlate well with the binding energies obtained from a computational model of the hOR17‐4 receptor.