DNA‐Based Carbohydrate Biochips: A Platform for Surface Glyco‐Engineering | Zendy

Chevolot Yann | Zendy; Bouillon Camille | Zendy; Vidal Sébastien | Zendy; Morvan François | Zendy; Meyer Albert | Zendy; Cloarec  JeanPierre | Zendy; Jochum Anne | Zendy; Praly JeanPierre | Zendy; Vasseur JeanJacques | Zendy; Souteyrand Eliane | Zendy

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DNA‐Based Carbohydrate Biochips: A Platform for Surface Glyco‐Engineering

Author(s) -

Chevolot Yann,

Bouillon Camille,

Vidal Sébastien,

Morvan François,

Meyer Albert,

Cloarec JeanPierre,

Jochum Anne,

Praly JeanPierre,

Vasseur JeanJacques,

Souteyrand Eliane

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200604955

Subject(s) - biochip , oligonucleotide , conjugate , carbohydrate , dna , lectin , chemistry , biochemistry , fluorescence , nanotechnology , combinatorial chemistry , computational biology , microbiology and biotechnology , computer science , materials science , biology , mathematics , physics , mathematical analysis , quantum mechanics

When the chips are down : A glycoarray consisting of oligonucleotide/carbohydrate conjugates hybridized onto a DNA chip can be used for the immobilization of oligosaccharides at extremely low concentrations (1 μ M ). With lectin, the lower detection limit of the device was 2–20 n m. The relative surface density of the conjugates was monitored by Cy3 fluorescence.

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