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Microfluidic Control of Fluorescence Resonance Energy Transfer: Breaking the FRET Limit
Author(s) -
Zhang Chunyang,
Johnson Lawrence W.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604861
Subject(s) - förster resonance energy transfer , microfluidics , nanosensor , detection limit , quantum dot , fluorescence , nanotechnology , limit (mathematics) , energy transfer , energy (signal processing) , chemistry , physics , materials science , chromatography , chemical physics , optics , quantum mechanics , mathematical analysis , mathematics
No empty FRET : The microfluidic control of fluorescence resonance energy transfer (FRET) has been demonstrated, and the FRET limit has been broken with a quantum‐dot (QD)‐based DNA nanosensor in a microfluidic flow. This nanosensor can detect long nucleic acids that have separation distances far beyond the range of FRET and whose detection is not feasible with conventional FRET‐based assays.