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Enantioselective Organocatalytic Conjugate Addition of N Heterocycles to α,β‐Unsaturated Aldehydes
Author(s) -
Dinér Peter,
Nielsen Martin,
Marigo Mauro,
Jørgensen Karl Anker
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604854
Subject(s) - enantioselective synthesis , conjugate , chemistry , catalysis , trimethylsilyl , organocatalysis , organic chemistry , mathematics , mathematical analysis
Must love cats.! Chiral amines catalyze the enantioselective addition of N‐heterocyclic compounds to α,β‐unsaturated compounds in high yields and with enantioselectivities of up to 94 % ee (see scheme; TMS=trimethylsilyl). The intermediates and transition states for the catalytic cycle were identified by performing DFT calculations.