A Multifunctional Light Switch: DNA Binding and Cleavage Properties of a Heterobimetallic Ruthenium–Rhenium Dipyridophenazine Complex | Zendy

Foxon Simon P. | Zendy; Phillips Tim | Zendy; Gill Martin R. | Zendy; Towrie Michael | Zendy; Parker Anthony W. | Zendy; Webb Michelle | Zendy; Thomas Jim A. | Zendy

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A Multifunctional Light Switch: DNA Binding and Cleavage Properties of a Heterobimetallic Ruthenium–Rhenium Dipyridophenazine Complex

Author(s) -

Foxon Simon P.,

Phillips Tim,

Gill Martin R.,

Towrie Michael,

Parker Anthony W.,

Webb Michelle,

Thomas Jim A.

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200604837

Subject(s) - phenazine , ruthenium , rhenium , tris , cleavage (geology) , dna , chemistry , stereochemistry , photochemistry , combinatorial chemistry , catalysis , materials science , biochemistry , organic chemistry , fracture (geology) , composite material

A DNA Swiss‐army knife : Photo‐ and biophysical studies on the hetero‐dinuclear complex [{Ru(tpm)(dppz)}(μ‐dpp[5]){ fac ‐(CO) 3 Re(dppz)}] 3+ (see structure; tpm=tris(1‐pyrazolyl)methane; dppz=dipyrido[3,2‐ a :2′,3′‐ c ]phenazine; dpp[5]=4,4′‐dipyridylpentane) reveal that it is both a DNA light switch and a direct cleaving agent.

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