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A Multifunctional Light Switch: DNA Binding and Cleavage Properties of a Heterobimetallic Ruthenium–Rhenium Dipyridophenazine Complex
Author(s) -
Foxon Simon P.,
Phillips Tim,
Gill Martin R.,
Towrie Michael,
Parker Anthony W.,
Webb Michelle,
Thomas Jim A.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604837
Subject(s) - phenazine , ruthenium , rhenium , tris , cleavage (geology) , dna , chemistry , stereochemistry , photochemistry , combinatorial chemistry , catalysis , materials science , biochemistry , organic chemistry , fracture (geology) , composite material
A DNA Swiss‐army knife : Photo‐ and biophysical studies on the hetero‐dinuclear complex [{Ru(tpm)(dppz)}(μ‐dpp[5]){ fac ‐(CO) 3 Re(dppz)}] 3+ (see structure; tpm=tris(1‐pyrazolyl)methane; dppz=dipyrido[3,2‐ a :2′,3′‐ c ]phenazine; dpp[5]=4,4′‐dipyridylpentane) reveal that it is both a DNA light switch and a direct cleaving agent.