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Chemically Immobilized Single‐Stranded Oligonucleotides on Praseodymium Oxide Nanoparticles as an Unlabeled DNA Sensor Probe Using Impedance
Author(s) -
Shrestha Sudha,
Yeung Connie M. Y.,
Mills Catherine E.,
Lewington Jay,
Tsang Shik Chi
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604827
Subject(s) - oligonucleotide , indium tin oxide , spark (programming language) , indium , nanoparticle , chemistry , capacitance , electrical impedance , lanthanide , oxide , combinatorial chemistry , analytical chemistry (journal) , dna , materials science , nanotechnology , computer science , chromatography , physics , optoelectronics , electrode , layer (electronics) , biochemistry , organic chemistry , ion , quantum mechanics , programming language
A spark of attraction : Ellipsoidal Pr 6 O 11 particles on indium tin oxide (ITO) modified with single‐stranded oliogonucleotides act as an unlabeled DNA probe. Upon recognition of complementary bases in solution, an impedance change (capacitance change) is detected. An equivalent impedance change is not obtained upon the addition of an oligonucleotide with slightly mismatched bases.