Premium
Molecular Recognition Drives Oligonucleotide Binding to Nucleolipid Self‐Assemblies
Author(s) -
Banchelli Martina,
Berti Debora,
Baglioni Piero
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604826
Subject(s) - oligonucleotide , supramolecular chemistry , divalent , polynucleotide , amphiphile , mesophase , crystallography , chemistry , hexagonal crystal system , dna , aqueous solution , nanotechnology , stereochemistry , combinatorial chemistry , materials science , copolymer , biochemistry , organic chemistry , polymer , crystal structure , phase (matter)
Ordered interactions : Selective supramolecular association of oligonucleotides with like‐charged amphiphilic self‐assemblies in aqueous solution, in the absence of divalent cations, is reported. A structural model of the nucleolipoplex, the ordered mesophase formed upon interaction of DNA (red) with anionic nucleolipid assemblies (green), is shown. The hexagonal arrangement is templated by the complementary polynucleotide.