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Rh‐Catalyzed Highly Enantioselective Synthesis of 3‐Arylbutanoic Acids
Author(s) -
Sun Xianfeng,
Zhou Le,
Wang ChunJiang,
Zhang Xumu
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604810
Subject(s) - enantioselective synthesis , catalysis , aryl , chemistry , ligand (biochemistry) , solvent , organic chemistry , combinatorial chemistry , chiral ligand , biochemistry , alkyl , receptor
It's in the mix : The reaction conditions—catalyst, additive, and solvent—have been optimized for the asymmetric hydrogenation of 3‐aryl‐3‐butenoic acids. The rigid, chiral bisphospholane ligand ( S p , R c )‐DuanPhos is crucial to achieving high enantioselectivity.