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Dynamic Hydrogels: Translating a Protein Conformational Change into Macroscopic Motion
Author(s) -
Murphy William L.,
Dillmore W. Shan,
Modica Justin,
Mrksich Milan
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604808
Subject(s) - conformational change , calmodulin , self healing hydrogels , acrylate , trifluoperazine , ligand (biochemistry) , biophysics , ethylene glycol , schematic , chemistry , materials science , polymer chemistry , stereochemistry , copolymer , biochemistry , polymer , organic chemistry , enzyme , receptor , biology , electronic engineering , engineering
Natural inspiration : A bioinspired functional material in the form of a hydrogel created by cross‐linking an engineered version of calmodulin, a protein which undergoes a conformational change in response to ligand binding (see schematic representation), with a four‐armed poly(ethylene glycol) molecule terminated with acrylate groups decreased in volume by 20 % when treated with the ligand trifluoperazine. Multiple cycles of gel swelling and shrinkage were possible.