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Total Synthesis of Candicanoside A, a Potent Antitumor Saponin with a Rearranged Steroid Side Chain
Author(s) -
Tang Pingping,
Yu Biao
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604761
Subject(s) - saponin , side chain , stereochemistry , chemistry , ring (chemistry) , combinatorial chemistry , mode of action , steroid , computer science , computational biology , biochemistry , medicine , biology , organic chemistry , alternative medicine , pathology , hormone , polymer
The fused‐ring scaffold of candicanoside A ( 1 ), a potent antitumor agent with a unique differential pattern, has now been synthesized from inexpensive starting materials. Compound 1 has the potential to act as a lead compound for the synthesis of antitumor agents with a novel mode of action.