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Multiplication of Human Natural Killer Cells by Nanosized Phosphonate‐Capped Dendrimers
Author(s) -
Griffe Laurent,
Poupot Mary,
Marchand Patrice,
Maraval Alexandrine,
Turrin CédricOlivier,
Rolland Olivier,
Métivier Pascal,
Bacquet Gérard,
Fournié JeanJacques,
Caminade AnneMarie,
Poupot Rémy,
Majoral JeanPierre
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604651
Subject(s) - dendrimer , phosphonate , peripheral blood mononuclear cell , multiplication (music) , peripheral blood , chemistry , natural (archaeology) , biology , computational biology , immunology , biochemistry , mathematics , in vitro , combinatorics , paleontology
Non‐natural born killers : The addition of phosphorus‐containing dendrimers capped with phosphonate end groups to cultures of human peripheral blood mononuclear cells (white blood cells) strongly stimulates the selective multiplication of functional natural killer (NK) cells (see picture), which play a key role in anticancer immunity. Both the generation of the dendrimer and the type of end groups are important criteria for the activity.