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Xerogel‐Encapsulated W110A Secondary Alcohol Dehydrogenase from Thermoanaerobacter ethanolicus Performs Asymmetric Reduction of Hydrophobic Ketones in Organic Solvents
Author(s) -
Musa Musa M.,
ZiegelmannFjeld Karla I.,
Vieille Claire,
Zeikus J. Gregory,
Phillips Robert S.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604615
Subject(s) - substituent , alcohol dehydrogenase , chemistry , alcohol , enzyme , organic chemistry , ring (chemistry) , reduction (mathematics) , combinatorial chemistry , geometry , mathematics
To gel well : The asymmetric reduction of hydrophobic ketones by xerogel‐immobilized W110A secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus (TeSADH) in organic solvents affords their S ‐configured alcohols in yields comparable with those achieved by using the free enzyme, and, in some cases, with higher enantioselectivities. R=phenyl‐ring‐containing substituent.