Xerogel‐Encapsulated W110A Secondary Alcohol Dehydrogenase from  Thermoanaerobacter ethanolicus  Performs Asymmetric Reduction of Hydrophobic Ketones in Organic Solvents | Zendy

Musa Musa M. | Zendy; ZiegelmannFjeld Karla I. | Zendy; Vieille Claire | Zendy; Zeikus J. Gregory | Zendy; Phillips Robert S. | Zendy

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Xerogel‐Encapsulated W110A Secondary Alcohol Dehydrogenase from Thermoanaerobacter ethanolicus Performs Asymmetric Reduction of Hydrophobic Ketones in Organic Solvents

Author(s) -

Musa Musa M.,

ZiegelmannFjeld Karla I.,

Vieille Claire,

Zeikus J. Gregory,

Phillips Robert S.

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200604615

Subject(s) - substituent , alcohol dehydrogenase , chemistry , alcohol , enzyme , organic chemistry , ring (chemistry) , reduction (mathematics) , combinatorial chemistry , geometry , mathematics

To gel well : The asymmetric reduction of hydrophobic ketones by xerogel‐immobilized W110A secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus (TeSADH) in organic solvents affords their S ‐configured alcohols in yields comparable with those achieved by using the free enzyme, and, in some cases, with higher enantioselectivities. R=phenyl‐ring‐containing substituent.

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