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Findings on the Electron‐Attachment‐Induced Abasic Site in a DNA Double Helix
Author(s) -
Gu Jiande,
Wang Jing,
Rak Janusz,
Leszczynski Jerzy
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604603
Subject(s) - ap site , helix (gastropod) , dna , chemistry , lees , a dna , dna damage , biophysics , biochemistry , biology , ecology , snail , fermentation
One for the road : The potential‐energy hyperface along the pathway of the formation of an abasic site (P abasic ) suggests that low‐energy electrons (LEEs) might induce the formation of such a site at the 3′ end of a DNA double helix with the strand ended in a cytidine residue. Attachment of these LEEs to a DNA helix might significantly contribute to radiation‐induced DNA damage. TS=transition state.