Two‐Photon Uncaging with the Efficient 3,5‐Dibromo‐2,4‐dihydroxycinnamic Caging Group | Zendy

Gagey Nathalie | Zendy; Neveu Pierre | Zendy; Jullien Ludovic | Zendy

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Two‐Photon Uncaging with the Efficient 3,5‐Dibromo‐2,4‐dihydroxycinnamic Caging Group

Author(s) -

Gagey Nathalie,

Neveu Pierre,

Jullien Ludovic

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200604598

Subject(s) - substrate (aquarium) , fluorescence , two photon excitation microscopy , chemistry , photochemistry , ethanol , excitation , in vivo , optoelectronics , materials science , optics , physics , biology , biochemistry , ecology , microbiology and biotechnology , quantum mechanics

An optical syringe for targeted delivery of a substrate in vivo has been developed on the basis of the 3,5‐dibromo‐2,4‐dihydroxycinnamic caging group. Two‐photon excitation of the caged compound uncages the substrate (ethanol in the scheme) and forms a coumarin whose fluorescence allows the concentration of released substrate to be quantified. Single‐cell release can be achieved with a focused laser (shown schematically for a zebrafish embryo).

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