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Total Synthesis of Tubulysins U and V
Author(s) -
Sani Monica,
Fossati Giacomo,
Huguenot Florent,
Zanda Matteo
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604557
Subject(s) - myxobacteria , sequence (biology) , modular design , total synthesis , stereochemistry , computational biology , combinatorial chemistry , chemistry , computer science , biology , biochemistry , programming language , genetics , bacteria
Meeting the challenge : A reliable and modular reaction sequence has been developed for the synthesis of the challenging tubulysin framework. This route allows preparation of hundreds of milligrams of the stereochemically pure tetrapeptides (see picture), which are produced in small amounts by two different species of myxobacteria. Thus, full biological evaluation of the tubulysins and their analogues is now a real possibility.

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