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Rapid Multiphase Carbonylation Reactions by Using a Microtube Reactor: Applications in Positron Emission Tomography 11 C‐Radiolabeling
Author(s) -
Miller Philip W.,
Long Nicholas J.,
de Mello Andrew J.,
Vilar Ramon,
Audrain Hélène,
Bender Dirk,
Passchier Jan,
Gee Antony
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604541
Subject(s) - carbonylation , carbon monoxide , palladium , catalysis , tube (container) , materials science , chemical reactor , chemistry , radiochemistry , chemical engineering , organic chemistry , composite material , engineering
Taking the tube : A silica‐supported palladium catalyst packed into teflon tubing is a simple, low‐cost, and effective method for carrying out carbonylative cross‐coupling reactions of arylhalides with amines and radiolabeled carbon monoxide gas. In carbonylation reactions, the microtube reactor displays enhanced yields over a short time period (12 min) compared with batch methods.