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The Sulfhydryl Radical (HS . /S .− ): A Contender for the Isomerization of Double Bonds in Membrane Lipids
Author(s) -
Lykakis Ioannis N.,
Ferreri Carla,
Chatgilialoglu Chryssostomos
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604525
Subject(s) - isomerization , chemistry , radical , membrane , double bond , hydrogen sulfide , hydrogen bond , biological membrane , suspension (topology) , vesicle , photochemistry , molecule , organic chemistry , biochemistry , catalysis , sulfur , mathematics , homotopy , pure mathematics
The biologically relevant gas hydrogen sulfide is a source of radicals that have been found to catalyze the cis – trans isomerization of unsaturated lipids in a vesicle suspension (see picture). This biomimetic model highlights the importance of double‐bond geometry in membrane lipids and has significance for the investigation of H 2 S activity (damaging and signaling) in a biological milieu.