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All‐Carbon Quaternary Stereogenic Centers by Enantioselective Cu‐Catalyzed Conjugate Additions Promoted by a Chiral N‐Heterocyclic Carbene
Author(s) -
Brown M. Kevin,
May Tricia L.,
Baxter Carl A.,
Hoveyda Amir H.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604511
Subject(s) - stereocenter , carbene , conjugate , enantioselective synthesis , catalysis , reagent , chemistry , carbon fibers , alkyl , quaternary carbon , combinatorial chemistry , organic chemistry , medicinal chemistry , materials science , mathematics , mathematical analysis , composite number , composite material
Necessity is the mother of invention : When the available catalysts do not cut it, a new one has to be developed. A chiral N‐heterocyclic carbene (NHC) is used in the first catalytic asymmetric conjugate addition of alkyl‐ and arylzinc reagents to γ‐keto esters (see scheme).