A New Approach for an Organocatalytic Multicomponent Domino Asymmetric Reaction | Zendy

Carlone Armando | Zendy; Cabrera Silvia | Zendy; Marigo Mauro | Zendy; Jørgensen Karl Anker | Zendy

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A New Approach for an Organocatalytic Multicomponent Domino Asymmetric Reaction

Author(s) -

Carlone Armando,

Cabrera Silvia,

Marigo Mauro,

Jørgensen Karl Anker

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200604479

Subject(s) - domino , stereocenter , domino effect , key (lock) , computer science , cascade reaction , trimethylsilyl , transformation (genetics) , combinatorial chemistry , chemistry , stereochemistry , enantioselective synthesis , medicinal chemistry , catalysis , organic chemistry , political science , operating system , biochemistry , gene , law

As easy as pouring! Three CC bonds, up to three stereocenters, and ee values greater than 97 % are created in a new organocatalyzed multicomponent domino reaction (see picture; TMS=trimethylsilyl; EWG=electron‐withdrawing group). Very high enantioselectivity, control of the substituents, easy handling, and user‐friendly reaction conditions are key features of this transformation.

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