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A New Approach for an Organocatalytic Multicomponent Domino Asymmetric Reaction
Author(s) -
Carlone Armando,
Cabrera Silvia,
Marigo Mauro,
Jørgensen Karl Anker
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604479
Subject(s) - domino , stereocenter , domino effect , key (lock) , computer science , cascade reaction , trimethylsilyl , transformation (genetics) , combinatorial chemistry , chemistry , stereochemistry , enantioselective synthesis , medicinal chemistry , catalysis , organic chemistry , political science , operating system , biochemistry , gene , law
As easy as pouring! Three CC bonds, up to three stereocenters, and ee values greater than 97 % are created in a new organocatalyzed multicomponent domino reaction (see picture; TMS=trimethylsilyl; EWG=electron‐withdrawing group). Very high enantioselectivity, control of the substituents, easy handling, and user‐friendly reaction conditions are key features of this transformation.