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Metallo‐ROS in Alzheimer's Disease: Oxidation of Neurotransmitters by Cu II ‐β‐Amyloid and Neuropathology of the Disease
Author(s) -
da Silva Giordano F. Z.,
Ming LiJune
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604421
Subject(s) - neuropathology , reactive oxygen species , hydroxylation , disease , amyloid (mycology) , chemistry , oxidative phosphorylation , oxidative damage , neuroscience , biochemistry , alzheimer's disease , oxidative stress , enzyme , psychology , medicine , inorganic chemistry
A clear mind : The Cu II –β‐amyloid (Aβ) complex has been shown to exhibit enzyme‐like metal‐centered oxidative and hydroxylation catalyses. Metal‐centered oxidation of various neurotransmitters by CuAβ under biomimetic conditions has verified the bio‐relevance of the metal‐centered catalyses and is expected to provide a chemical basis for the better understanding of the etiology of Alzheimer's disease. ROS=reactive oxygen species.