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Chirality‐Controlled Formation of β‐Turn Secondary Structures in Short Peptide Chains: Gas‐Phase Experiment versus Quantum Chemistry
Author(s) -
Brenner Valérie,
Piuzzi François,
Dimicoli Iliana,
Tardivel Benjamin,
Mons Michel
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604416
Subject(s) - gas phase , turn (biochemistry) , chemistry , chirality (physics) , spectroscopy , protein secondary structure , supersonic speed , quantum chemical , quantum , phase (matter) , chemical physics , peptide , quantum chemistry , laser , molecular physics , crystallography , stereochemistry , physics , molecule , optics , organic chemistry , reaction mechanism , catalysis , quantum mechanics , thermodynamics , biochemistry , chiral symmetry breaking , nambu–jona lasinio model , quark
Spontaneous formation of secondary structures (i.e., β‐turns) by isolated capped dipeptides in the gas phase was investigated by laser spectroscopy following supersonic expansion, and by quantum chemical calculations. The two most stable calculated β‐turn structures I and II′ of one of the dipeptides were related to species B and B′, respectively, identified in the near‐UV spectrum (see figure).