The Azaallylic Anion as a Synthon for Pd‐Catalyzed Synthesis of Heterocycles: Domino Two‐ and Three‐Component Synthesis of Indoles | Zendy

Barluenga José | Zendy; JiménezAquino Agustín | Zendy; Valdés Carlos | Zendy; Aznar Fernando | Zendy

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The Azaallylic Anion as a Synthon for Pd‐Catalyzed Synthesis of Heterocycles: Domino Two‐ and Three‐Component Synthesis of Indoles

Author(s) -

Barluenga José,

JiménezAquino Agustín,

Valdés Carlos,

Aznar Fernando

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200604407

Subject(s) - synthon , domino , catalysis , palladium , component (thermodynamics) , chemistry , combinatorial chemistry , cascade reaction , cascade , organic chemistry , physics , chromatography , thermodynamics

Piecing it all together with palladium : Two‐ and three‐component cascade processes that are promoted by a multifunctional Pd catalyst lead to indoles in a highly efficient manner (see scheme). The key step is the Pd‐catalyzed α‐arylation of imines with o ‐dihalobenzene derivatives.

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