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The Azaallylic Anion as a Synthon for Pd‐Catalyzed Synthesis of Heterocycles: Domino Two‐ and Three‐Component Synthesis of Indoles
Author(s) -
Barluenga José,
JiménezAquino Agustín,
Valdés Carlos,
Aznar Fernando
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604407
Subject(s) - synthon , domino , catalysis , palladium , component (thermodynamics) , chemistry , combinatorial chemistry , cascade reaction , cascade , organic chemistry , physics , chromatography , thermodynamics
Piecing it all together with palladium : Two‐ and three‐component cascade processes that are promoted by a multifunctional Pd catalyst lead to indoles in a highly efficient manner (see scheme). The key step is the Pd‐catalyzed α‐arylation of imines with o ‐dihalobenzene derivatives.