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Notoamides A–D: Prenylated Indole Alkaloids Isolated from a Marine‐Derived Fungus, Aspergillus sp.
Author(s) -
Kato Hikaru,
Yoshida Takushi,
Tokue Takanori,
Nojiri Yuka,
Hirota Hiroshi,
Ohta Tomihisa,
Williams Robert M.,
Tsukamoto Sachiko
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604381
Subject(s) - indole test , fungus , prenylation , aspergillus , marine fungi , indole alkaloid , stereochemistry , chemistry , botany , biology , organic chemistry , enzyme
Mussel power : The structures and configurations have been determined of four new indole alkaloids, notoamides A–D, which were isolated from mussel‐derived Aspergillus sp. Notoamides A–C show moderate cytotoxicity against cancer cell lines. The relationship between these and other metabolites suggests that the fungus uses a diverse biosynthetic pathway.