A Concise, Biomimetic Total Synthesis of Stephacidin A and Notoamide B | Zendy

Greshock Thomas J. | Zendy; Grubbs Alan W. | Zendy; Tsukamoto Sachiko | Zendy; Williams Robert M. | Zendy

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A Concise, Biomimetic Total Synthesis of Stephacidin A and Notoamide B

Author(s) -

Greshock Thomas J.,

Grubbs Alan W.,

Tsukamoto Sachiko,

Williams Robert M.

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200604378

Subject(s) - copying , total synthesis , intramolecular force , scheme (mathematics) , oxaziridine , content (measure theory) , nonsense , chemistry , computer science , stereochemistry , mathematics , political science , law , biochemistry , mathematical analysis , gene

Copying nature : A biomimetic total synthesis of stephacidin A has been accomplished using an intramolecular Diels–Alder reaction. Stephacidin A was then converted into notoamide B in a single step by oxaziridine‐mediated oxidation to provide the first biomimetic total synthesis of notoamide B (see scheme).

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