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The Enantioselective Morita–Baylis–Hillman Reaction and Its Aza Counterpart
Author(s) -
Masson Géraldine,
Housseman Christopher,
Zhu Jieping
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604366
Subject(s) - enantioselective synthesis , organocatalysis , bifunctional , chemistry , organic synthesis , morita therapy , combinatorial chemistry , catalysis , stereochemistry , organic chemistry , mathematics , pure mathematics
The development of asymmetric Morita–Baylis–Hillman (MBH) reactions has evolved dramatically over the past few years, parallel to the emerging concept of bifunctional organocatalysis. Whereas organocatalysis is starting to compete with metal‐based catalysis in several important organic transformations, the MBH reaction belongs to a group of prototypical reactions in which organocatalysts already display superiority over their metal‐based counterparts. This Minireview summarizes recent mechanistic insights and advances in the design and synthesis of small organic molecules for enantioselective MBH and aza‐MBH reactions.