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Catalytic Asymmetric Synthesis of Tertiary Alkyl Chlorides
Author(s) -
Lee Elaine C.,
McCauley Kevin M.,
Fu Gregory C.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604312
Subject(s) - alkyl , catalysis , chemistry , computer science , combinatorial chemistry , organic chemistry
Ketenes are coupled with 2,2,6,6‐tetrachlorocyclohexanone in a catalytic asymmetric method for the synthesis of tertiary α‐chloroesters (see scheme). This complements recent progress in the generation of secondary α‐halocarbonyl compounds.