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Synthesis of Stable Isothiazole Carbenes
Author(s) -
Wolf Janine,
Böhlmann Winfried,
Findeisen Matthias,
Gelbrich Thomas,
Hofmann HansJörg,
Schulze Bärbel
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604305
Subject(s) - carbene , deprotonation , isothiazole , chemistry , singlet state , nuclear magnetic resonance spectroscopy , state (computer science) , combinatorial chemistry , computational chemistry , stereochemistry , polymer chemistry , medicinal chemistry , organic chemistry , computer science , physics , catalysis , nuclear physics , programming language , ion , excited state
Through deprotonation of isothiazolium salts, stable substituted singlet carbenes of isothiazol‐3‐ylidenes (see scheme) could be synthesized for the first time. The carbenes, which were characterized by solid‐state and solution NMR spectroscopy, undergo typical carbene reactions, such as dimerization and insertion into polarized XH bonds, and might be important for a number of further reactions.