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siRNA Delivery into Human T Cells and Primary Cells with Carbon‐Nanotube Transporters
Author(s) -
Liu Zhuang,
Winters Mark,
Holodniy Mark,
Dai Hongjie
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200604295
Subject(s) - small interfering rna , gene silencing , carbon nanotube , microbiology and biotechnology , cell , human immunodeficiency virus (hiv) , drug delivery , transporter , nanotechnology , transfection , chemistry , materials science , biology , virology , gene , biochemistry
Special delivery : Functionalized single‐walled nanotubes (SWNT) can be used as molecular transporters to shuttle short interfering RNA (siRNA) into human T cells and primary cells and silence the expression of HIV‐specific cell‐surface receptors and coreceptors (see picture; scale bars 40 μm). This silencing effect, known to block HIV viral entry and reduce infection, is superior to that observed with conventional liposome‐based nonviral delivery agents.